Endothelin Limits Insulin Action in Obese/Insulin-Resistant Humans

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Endothelin limits insulin action in obese/insulin-resistant humans.

The normal action of insulin to vasodilate and redistribute blood flow in support of skeletal muscle metabolism is impaired in insulin-resistant states. Increased endogenous endothelin contributes to endothelial dysfunction in obesity and diabetes. Here, we test the hypothesis that increased endogenous endothelin action also contributes to skeletal muscle insulin resistance via impairments in i...

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ژورنال

عنوان ژورنال: Diabetes

سال: 2007

ISSN: 0012-1797,1939-327X

DOI: 10.2337/db06-1406